Goats without Prion Protein Display Enhanced Proinflammatory Pulmonary Signaling and Extracellular Matrix Remodeling upon Systemic Lipopolysaccharide Challenge

A naturally occurring mutation in the PRNP gene of Norwegian dairy goats terminates synthesis of the cellular prion protein (PrP(C)), rendering homozygous goats (PRNP(Ter/Ter)) devoid of the protein. Although PrP(C) has been extensively studied, particularly in the central nervous system, the biolog...

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Pubblicato in:Front Immunol
Autori principali: Salvesen, Øyvind, Reiten, Malin R., Kamstra, Jorke H., Bakkebø, Maren K., Espenes, Arild, Tranulis, Michael A., Ersdal, Cecilie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5723645/
https://ncbi.nlm.nih.gov/pubmed/29270176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01722
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