Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation

Meningiomas frequently display activation of the PI3K/AKT/mTOR pathway, leading to elevated levels of phospho-4E binding proteins, which enhances protein synthesis; however, it is not known whether inhibition of protein translation is an effective treatment option for meningiomas. We found that huma...

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Pubblicato in:Exp Neurol
Autori principali: Oblinger, Janet L., Burns, Sarah S., Huang, Jie, Pan, Li, Ren, Yulin, Shen, Rulong, Kinghorn, A. Douglas, Welling, D. Bradley, Chang, Long-Sheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5723558/
https://ncbi.nlm.nih.gov/pubmed/28610844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2017.06.015
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