Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas

BACKGROUND: The eukaryotic initiation factor 4F (eIF4F) complex plays a pivotal role in protein translation initiation; however, its importance in malignant and benign Schwann cell tumors has not been explored, and whether blocking eIF4F function is effective for treating these tumors is not known....

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Oblinger, Janet L., Burns, Sarah S., Akhmametyeva, Elena M., Huang, Jie, Pan, Li, Ren, Yulin, Shen, Rulong, Miles-Markley, Beth, Moberly, Aaron C., Kinghorn, A. Douglas, Welling, D. Bradley, Chang, Long-Sheng
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Basic and Translational Investigation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998994/
https://ncbi.nlm.nih.gov/pubmed/26951381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now032
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