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Recent progress in dissecting molecular recognition by DNA polymerases with non-native substrates
DNA polymerases must discriminate the correct Watson-Crick base pair-forming deoxynucleoside triphosphate (dNTP) substrate from three other dNTPs and additional triphosphates found in the cell. The rarity of misincorporations in vivo, then, belies the high tolerance for dNTP analogs observed in vitr...
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| Published in: | Curr Opin Chem Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5723536/ https://ncbi.nlm.nih.gov/pubmed/29096323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2017.10.005 |
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