Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

The structural transitions required for insulin to activate its receptor and initiate regulation of glucose homeostasis are only partly understood. Here, using ring-closing metathesis, we substitute the A6-A11 disulfide bond of insulin with a rigid, non-reducible dicarba linkage, yielding two distin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: van Lierop, Bianca, Ong, Shee Chee, Belgi, Alessia, Delaine, Carlie, Andrikopoulos, Sofianos, Haworth, Naomi L., Menting, John G., Lawrence, Michael C., Robinson, Andrea J., Forbes, Briony E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722942/
https://ncbi.nlm.nih.gov/pubmed/29222417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16876-3
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