Probing the correlation between insulin activity and structural stability through introduction of the rigid A6–A11 bond

The development of fast-acting and highly stable insulin analogues is challenging. Insulin undergoes structural transitions essential for binding and activation of the insulin receptor (IR), but these conformational changes can also affect insulin stability. Previously, we substituted the insulin A6...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ong, Shee Chee, Belgi, Alessia, van Lierop, Bianca, Delaine, Carlie, Andrikopoulos, Sofianos, MacRaild, Christopher A., Norton, Raymond S., Haworth, Naomi L., Robinson, Andrea J., Forbes, Briony E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066309/
https://ncbi.nlm.nih.gov/pubmed/29899115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002486
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