Probing the correlation between insulin activity and structural stability through introduction of the rigid A6–A11 bond

The development of fast-acting and highly stable insulin analogues is challenging. Insulin undergoes structural transitions essential for binding and activation of the insulin receptor (IR), but these conformational changes can also affect insulin stability. Previously, we substituted the insulin A6...

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Vydáno v:J Biol Chem
Hlavní autoři: Ong, Shee Chee, Belgi, Alessia, van Lierop, Bianca, Delaine, Carlie, Andrikopoulos, Sofianos, MacRaild, Christopher A., Norton, Raymond S., Haworth, Naomi L., Robinson, Andrea J., Forbes, Briony E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066309/
https://ncbi.nlm.nih.gov/pubmed/29899115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002486
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