Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse

We generated a novel mouse strain expressing transgenic human interleukin-15 (IL-15) using the severe immunodeficient NOD/Shi-scid-IL-2Rγ(null) (NOG) mouse genetic background (NOG-IL-15 Tg). Human natural killer (NK) cells, purified from the peripheral blood (hu-PB-NK) of normal healthy donors, prol...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Katano, Ikumi, Nishime, Chiyoko, Ito, Ryoji, Kamisako, Tsutomu, Mizusawa, Takuma, Ka, Yuyo, Ogura, Tomoyuki, Suemizu, Hiroshi, Kawakami, Yutaka, Ito, Mamoru, Takahashi, Takeshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722902/
https://ncbi.nlm.nih.gov/pubmed/29222435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17442-7
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