HEB is required for the specification of fetal IL-17-producing γδ T cells

IL-17-producing γδ T (γδT17) cells are critical components of the innate immune system. However, the gene networks that control their development are unclear. Here we show that HEB (HeLa E-box binding protein, encoded by Tcf12) is required for the generation of a newly defined subset of fetal-derive...

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Udgivet i:Nat Commun
Main Authors: In, Tracy S. H., Trotman-Grant, Ashton, Fahl, Shawn, Chen, Edward L. Y., Zarin, Payam, Moore, Amanda J., Wiest, David L., Zúñiga-Pflücker, Juan Carlos, Anderson, Michele K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722817/
https://ncbi.nlm.nih.gov/pubmed/29222418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02225-5
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