Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart

RATIONALE: Intercellular uncoupling and Ca mishandling can initiate triggered ventricular arrhythmias. Spontaneous Ca release activates inward current which depolarizes membrane potential (V(m)) and can trigger action potentials in isolated myocytes. However, cell-cell coupling in intact hearts limi...

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Udgivet i:Circ Res
Main Authors: Lang, Di, Sato, Daisuke, Jiang, Yan, Ginsburg, Kenneth, Ripplinger, Crystal M., Bers, Donald M.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722688/
https://ncbi.nlm.nih.gov/pubmed/28970285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.312050
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