C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid

Complement activation correlates to rheumatoid arthritis disease activity, and increased amounts of the complement split product C5a is observed in synovial fluids from rheumatoid arthritis patients. Blockade of C5a or its receptor (C5aR) is efficacious in several arthritis models. The aim of this s...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Hornum, Lars, Hansen, Anker Jon, Tornehave, Ditte, Fjording, Marianne Scheel, Colmenero, Paula, Wätjen, Inger Falbe, Søe Nielsen, Niels Henrik, Bliddal, Henning, Bartels, Else Marie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722346/
https://ncbi.nlm.nih.gov/pubmed/29220376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189017
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