The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction

The complement anaphylatoxin C5a is a proinflammatory component of host defense that functions through two identified receptors, C5a receptor (C5aR) and C5L2. C5aR is a classical G protein-coupled receptor, whereas C5L2 is structurally homologous but deficient in G protein coupling. In human neutrop...

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Bibliographic Details
Main Authors: Bamberg, Claire E., Mackay, Charles R., Lee, Hyun, Zahra, David, Jackson, Jenny, Lim, Yun Si, Whitfeld, Peter L., Craig, Stewart, Corsini, Erin, Lu, Bao, Gerard, Craig, Gerard, Norma P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844210/
https://ncbi.nlm.nih.gov/pubmed/20044484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092106
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