C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid

Complement activation correlates to rheumatoid arthritis disease activity, and increased amounts of the complement split product C5a is observed in synovial fluids from rheumatoid arthritis patients. Blockade of C5a or its receptor (C5aR) is efficacious in several arthritis models. The aim of this s...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hornum, Lars, Hansen, Anker Jon, Tornehave, Ditte, Fjording, Marianne Scheel, Colmenero, Paula, Wätjen, Inger Falbe, Søe Nielsen, Niels Henrik, Bliddal, Henning, Bartels, Else Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722346/
https://ncbi.nlm.nih.gov/pubmed/29220376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189017
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