Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer

The anticancer properties of ceramide, a sphingolipid with potent tumor-suppressor properties, can be dampened via glycosylation, notably in multidrug resistance wherein ceramide glycosylation is characteristically elevated. Earlier works using the ceramide analog, C6-ceramide, demonstrated that the...

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Udgivet i:Biochem Pharmacol
Main Authors: Morad, Samy A. F., Davis, Traci S., MacDougall, Matthew R., Tan, Su-Fern, Feith, David J., Desai, Dhimant H., Amin, Shantu G., Kester, Mark, Loughran, Thomas P., Cabot, Myles C.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722210/
https://ncbi.nlm.nih.gov/pubmed/28189725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.02.002
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