The selective peroxisome proliferator–activated receptor‐delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice

Lipotoxicity associated with insulin resistance is central to nonalcoholic steatohepatitis (NASH) pathogenesis. To date, only weight loss fully reverses NASH pathology, but mixed peroxisome proliferator–activated receptor‐alpha/delta (PPAR‐α/δ) agonists show some efficacy. Seladelpar (MBX‐8025), a s...

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Detalhes bibliográficos
Publicado no:Hepatol Commun
Main Authors: Haczeyni, Fahrettin, Wang, Hans, Barn, Vanessa, Mridha, Auvro R., Yeh, Matthew M., Haigh, W. Geoffrey, Ioannou, George N., Choi, Yun‐Jung, McWherter, Charles A., Teoh, Narcissus C.‐H., Farrell, Geoffrey C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5721439/
https://ncbi.nlm.nih.gov/pubmed/29404484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1072
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