A Robust System for Production of Superabundant VP1 Recombinant AAV Vectors

Recombinant adeno-associated viral (rAAV) vectors have been widely used in human gene therapy. One major impediment to its broad application is the inability to produce high-quality vectors in mass quantity. Here, an efficient and scalable suspension cell culture system for the production of rAAV ve...

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Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Wang, Qizhao, Wu, Zhongren, Zhang, Junping, Firrman, Jenni, Wei, Hongying, Zhuang, Zhengjing, Liu, LinShu, Miao, Linqing, Hu, Yang, Li, Dong, Diao, Yong, Xiao, Weidong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5721209/
https://ncbi.nlm.nih.gov/pubmed/29255740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.11.002
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