ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis

Maladaptive wound healing responses to chronic tissue injury result in organ fibrosis. Fibrosis, which entails excessive extracellular matrix (ECM) deposition and tissue remodelling by activated myofibroblasts, leads to loss of proper tissue architecture and organ function; however the molecular med...

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Publicado en:Nat Med
Main Authors: Lagares, David, Ghassemi-Kakroodi, Parisa, Tremblay, Caroline, Santos, Alba, Probst, Clemens K., Franklin, Alicia, Santos, Daniela M., Grasberger, Paula, Ahluwalia, Neil, Montesi, Sydney B., Shea, Barry S., Black, Katharine E., Knipe, Rachel, Blati, Meryem, Baron, Murray, Wu, Brian, Fahmi, Hassan, Gandhi, Rajiv, Pardo, Annie, Selman, Moisés, Wu, Jiangping, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Tager, Andrew M., Kapoor, Mohit
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720906/
https://ncbi.nlm.nih.gov/pubmed/29058717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4419
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