Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

Novel l-valinate amide benzoxaboroles and analogues were designed and synthesized for a structure-activity-relationship (SAR) investigation to optimize the growth inhibitory activity against Trypanosoma congolense (T. congolense) and Trypanosoma vivax (T. vivax) parasites. The study identified 4-flu...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Ltd 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720837/
https://ncbi.nlm.nih.gov/pubmed/29169674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.11.028
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