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Enzyme Architecture: Erection of Active Orotidine 5′-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes
[Image: see text] Orotidine 5′-monophosphate decarboxylase (OMPDC) catalyzes the decarboxylation of 5-fluoroorotate (FO) with k(cat)/K(m) = 1.4 × 10(–7) M(–1) s(–1). Combining this and related kinetic parameters shows that the 31 kcal/mol stabilization of the transition state for decarboxylation of...
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| Veröffentlicht in: | J Am Chem Soc |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2017
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5720041/ https://ncbi.nlm.nih.gov/pubmed/29058891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08897 |
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