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Mechanistic insights into thrombin’s switch between “slow” and “fast” forms()

Thrombin is a multifunctional enzyme that plays an important role in blood coagulation, cell growth, and metastasis. Depending upon the binding of sodium ions, thrombin presents significantly different enzymatic activities. In the environment with sodium ions, thrombin is highly active in cleaving t...

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Detalhes bibliográficos
Publicado no:Phys Chem Chem Phys
Main Authors: Xiao, Jiajie, Melvin, Ryan L., Salsbury, Freddie R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719506/
https://ncbi.nlm.nih.gov/pubmed/28849814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cp03671j
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