ABT-263 induces G(1)/G(0)-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro

Both the anti- and pro-apoptotic members of the Bcl-2 family are regulated by a conserved Bcl-2 homology (BH3) domain. ABT-263 (Navitoclax), a novel BH3 mimetic and orally bioavailable Bcl-2 family inhibitor with high affinity for Bcl-xL, Bcl-2 and Bcl-w has entered clinical trials for cancer treatm...

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Bibliografiske detaljer
Udgivet i:Acta Pharmacol Sin
Main Authors: Lin, Qing-huan, Que, Fu-chang, Gu, Chun-ping, Zhong, De-sheng, Zhou, Dan, Kong, Yi, Yu, Le, Liu, Shu-wen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719159/
https://ncbi.nlm.nih.gov/pubmed/28713162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.78
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