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ABT-263 induces G(1)/G(0)-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro
Both the anti- and pro-apoptotic members of the Bcl-2 family are regulated by a conserved Bcl-2 homology (BH3) domain. ABT-263 (Navitoclax), a novel BH3 mimetic and orally bioavailable Bcl-2 family inhibitor with high affinity for Bcl-xL, Bcl-2 and Bcl-w has entered clinical trials for cancer treatm...
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| Gepubliceerd in: | Acta Pharmacol Sin |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5719159/ https://ncbi.nlm.nih.gov/pubmed/28713162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.78 |
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