Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells

Lymphodepletion chemotherapy followed by infusion of CD19-targeted chimeric antigen receptor (CAR)-modified T (CAR-T) cells can be complicated by neurologic adverse events (AEs) in patients with refractory B cell malignancies. In 133 adults treated with CD19 CAR-T cells we found that acute lymphobla...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Gust, Juliane, Hay, Kevin A., Hanafi, Laïla-Aïcha, Li, Daniel, Myerson, David, Gonzalez-Cuyar, Luis F., Yeung, Cecilia, Liles, W. Conrad, Wurfel, Mark, Lopez, Jose A., Chen, Junmei, Chung, Dominic, Harju-Baker, Susanna, Özpolat, Tahsin, Fink, Kathleen R., Riddell, Stanley R., Maloney, David G., Turtle, Cameron J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718945/
https://ncbi.nlm.nih.gov/pubmed/29025771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0698
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados