Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy

Lymphodepletion chemotherapy followed by infusion of CD19-specific chimeric antigen receptor–modified (CAR) T cells has produced impressive antitumor responses in patients with refractory CD19(+) B-cell malignancies but is often associated with cytokine release syndrome (CRS). Our understanding of C...

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Vydáno v:Blood
Hlavní autoři: Hay, Kevin A., Hanafi, Laïla-Aïcha, Li, Daniel, Gust, Juliane, Liles, W. Conrad, Wurfel, Mark M., López, José A., Chen, Junmei, Chung, Dominic, Harju-Baker, Susanna, Cherian, Sindhu, Chen, Xueyan, Riddell, Stanley R., Maloney, David G., Turtle, Cameron J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Immunobiology and Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701525/
https://ncbi.nlm.nih.gov/pubmed/28924019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-06-793141
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