Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells

Lymphodepletion chemotherapy followed by infusion of CD19-targeted chimeric antigen receptor (CAR)-modified T (CAR-T) cells can be complicated by neurologic adverse events (AEs) in patients with refractory B cell malignancies. In 133 adults treated with CD19 CAR-T cells we found that acute lymphobla...

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Bibliografski detalji
Izdano u:Cancer Discov
Glavni autori: Gust, Juliane, Hay, Kevin A., Hanafi, Laïla-Aïcha, Li, Daniel, Myerson, David, Gonzalez-Cuyar, Luis F., Yeung, Cecilia, Liles, W. Conrad, Wurfel, Mark, Lopez, Jose A., Chen, Junmei, Chung, Dominic, Harju-Baker, Susanna, Özpolat, Tahsin, Fink, Kathleen R., Riddell, Stanley R., Maloney, David G., Turtle, Cameron J.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718945/
https://ncbi.nlm.nih.gov/pubmed/29025771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0698
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