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The allosteric AKT inhibitor, MK2206, decreases tumor growth and invasion in patient derived xenografts of endometrial cancer

The purpose of this study was to test the effect of MK2206, an allosteric inhibitor of AKT, on the growth and invasion of patient-derived xenografts (PDX) of endometrial cancer. Three PDX lines, USC1 (uterine serous), EEC2 (endometrioid grade 2) and EEC4 (endometrioid grade 3) of endometrial cancer...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Winder, Abigail, Unno, Kenji, Yu, Yanni, Lurain, John, Kim, J. Julie
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718805/
https://ncbi.nlm.nih.gov/pubmed/28112582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1281496
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