Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo

AIM: Protein kinase B (AKT) signaling frequently is deregulated in human cancers and plays an important role in nasopharyngeal carcinoma (NPC). This preclinical study investigated the effect of MK-2206, a potent allosteric AKT inhibitor, on human NPC cells in vitro and in vivo. METHODS: The effect o...

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Autori principali: Zhao, Yuan-Yuan, Tian, Ying, Zhang, Jing, Xu, Fei, Yang, Yun-Peng, Huang, Yan, Zhao, Hong-Yun, Zhang, Jian-Wei, Xue, Cong, Lam, Michael H, Yan, Li, Hu, Zhi-Huang, Dinglin, Xiao-Xiao, Zhang, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2014
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199975/
https://ncbi.nlm.nih.gov/pubmed/25336925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S67961
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