Pharmacokinetics of IGF-1 in PAPP-A2-Deficient Patients, Growth Response, and Effects on Glucose and Bone Density

CONTEXT: The pregnancy-associated plasma protein A2 (PAPP-A2) cleaves insulinlike growth factor binding proteins 3 and 5, releasing free insulinlike growth factor 1 (IGF-1). Homozygous mutations in PAPP-A2 result in growth failure with elevated total but low free IGF-1. OBJECTIVE: To determine the 2...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Cabrera-Salcedo, Catalina, Mizuno, Tomoyuki, Tyzinski, Leah, Andrew, Melissa, Vinks, Alexander A., Frystyk, Jan, Wasserman, Halley, Gordon, Catherine M., Hwa, Vivian, Backeljauw, Philippe, Dauber, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2017
Assuntos:
Clinical Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718699/
https://ncbi.nlm.nih.gov/pubmed/29029190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2017-01411
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