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The functional domains for BaxΔ2 aggregate-mediated caspase 8-dependent cell death
BaxΔ2 is a functional pro-apoptotic Bax isoform having alterations in its N-terminus, but sharing the rest of its sequence with Baxα. BaxΔ2 is unable to target mitochondria due to the loss of helix α1. Instead, it forms cytosolic aggregates and activates caspase 8. However, the functional domain(s)...
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| Gepubliceerd in: | Exp Cell Res |
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| Hoofdauteurs: | , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5718386/ https://ncbi.nlm.nih.gov/pubmed/28807790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2017.08.016 |
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