Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo

Sphingosine-1-phospate is a potent bioactive lipid metabolite that regulates cancer progression. Because sphingosine kinase 1 and sphingosine kinase 2 (SPHK 1/2) are both essential for sphingosine-1-phospate production, they could be a therapeutic target in various cancers. Peretinoin, an acyclic re...

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Vydáno v:Sci Rep
Hlavní autoři: Funaki, Masaya, Kitabayashi, Juria, Shimakami, Tetsuro, Nagata, Naoto, Sakai, Yuriko, Takegoshi, Kai, Okada, Hikari, Murai, Kazuhisa, Shirasaki, Takayoshi, Oyama, Takeru, Yamashita, Taro, Ota, Tsuguhito, Takuwa, Yoh, Honda, Masao, Kaneko, Shuichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717167/
https://ncbi.nlm.nih.gov/pubmed/29208982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17285-2
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