Inhibition of A(2A) Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455

Several evidences indicate that the ubiquitous nucleoside adenosine, acting through A(1), A(2A), A(2B), and A(3) receptor (AR) subtypes, plays crucial roles in tumor development. Adenosine has contrasting effects on cell proliferation depending on the engagement of different receptor subtypes in var...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Gessi, Stefania, Bencivenni, Serena, Battistello, Enrica, Vincenzi, Fabrizio, Colotta, Vittoria, Catarzi, Daniela, Varano, Flavia, Merighi, Stefania, Borea, Pier Andrea, Varani, Katia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716981/
https://ncbi.nlm.nih.gov/pubmed/29249971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00888
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