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BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells

Aerobic glycolysis, a phenomenon known historically as the Warburg effect, is one of the hallmarks of cancer cells. In this study, we characterized the role of BAG3 in aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) and its molecular mechanisms. Our data show that aberrant expression o...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: An, Ming-Xin, Li, Si, Yao, Han-Bing, Li, Chao, Wang, Jia-Mei, Sun, Jia, Li, Xin-Yu, Meng, Xiao-Na, Wang, Hua-Qin
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716268/
https://ncbi.nlm.nih.gov/pubmed/29114069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201701064
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