BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells

Aerobic glycolysis, a phenomenon known historically as the Warburg effect, is one of the hallmarks of cancer cells. In this study, we characterized the role of BAG3 in aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) and its molecular mechanisms. Our data show that aberrant expression o...

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Vydáno v:J Cell Biol
Hlavní autoři: An, Ming-Xin, Li, Si, Yao, Han-Bing, Li, Chao, Wang, Jia-Mei, Sun, Jia, Li, Xin-Yu, Meng, Xiao-Na, Wang, Hua-Qin
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716268/
https://ncbi.nlm.nih.gov/pubmed/29114069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201701064
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