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USP1–UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses
Optimal activation of TANK-binding kinase 1 (TBK1) is crucial for initiation of innate antiviral immunity and maintenance of immune homeostasis. Although several E3 ubiquitin ligases have been reported to regulate TBK1 activation by mediating its polyubiquitination, the functions of deubiquitinase o...
Tallennettuna:
| Julkaisussa: | J Exp Med |
|---|---|
| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The Rockefeller University Press
2017
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5716033/ https://ncbi.nlm.nih.gov/pubmed/29138248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170180 |
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