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UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression

NOD-like receptor protein 3 (NLRP3) detects microbial infections or endogenous danger signals and activates the NLRP3 inflammasome, which has important functions in host defense and contributes to the pathogenesis of inflammatory diseases, and thereby needs to be tightly controlled. Deubiquitination...

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Vydáno v:Nat Commun
Hlavní autoři: Song, Hui, Zhao, Chunyuan, Yu, Zhongxia, Li, Qizhao, Yan, Rongzhen, Qin, Ying, Jia, Mutian, Zhao, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695691/
https://ncbi.nlm.nih.gov/pubmed/33247121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19939-8
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