Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Caloric restriction mimetics (CRMs) mimic the biochemical effects of nutrient deprivation by reducing lysine acetylation of cellular proteins, thus triggering autophagy. Treatment with the CRM hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T cells (which dampe...

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Publicat a:Cancer Cell
Autors principals: Pietrocola, Federico, Pol, Jonathan, Vacchelli, Erika, Rao, Shuan, Enot, David P., Baracco, Elisa E., Levesque, Sarah, Castoldi, Francesca, Jacquelot, Nicolas, Yamazaki, Takahiro, Senovilla, Laura, Marino, Guillermo, Aranda, Fernando, Durand, Sylvère, Sica, Valentina, Chery, Alexis, Lachkar, Sylvie, Sigl, Verena, Bloy, Norma, Buque, Aitziber, Falzoni, Simonetta, Ryffel, Bernhard, Apetoh, Lionel, Di Virgilio, Francesco, Madeo, Frank, Maiuri, Maria Chiara, Zitvogel, Laurence, Levine, Beth, Penninger, Josef M., Kroemer, Guido
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715805/
https://ncbi.nlm.nih.gov/pubmed/27411589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.05.016
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