Increasing the length and hydrophobicity of the C‐terminal sequence of transthyretin strengthens its binding affinity to retinol binding protein

Transthyretin (TTR) is a transporter for thyroid hormone (TH) and retinol, the latter via binding with retinol binding protein (RBP). Both the N‐terminal and C‐terminal regions of the TTR subunit are located in close proximity to the central binding channel for ligands. During the evolution of verte...

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Bibliografiske detaljer
Udgivet i:FEBS Open Bio
Main Authors: Poodproh, Rattawan, Kaewmeechai, Supavadee, Leelawatwattana, Ladda, Prapunpoj, Porntip
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715260/
https://ncbi.nlm.nih.gov/pubmed/29226076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12329
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