Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein

Preventing the protein-protein interaction of the cellular chromatin binding protein Lens Epithelium-Derived Growth Factor (LEDGF) and human immunodeficiency virus (HIV) integrase is an important possible strategy for anti-viral treatment for AIDS. We have used Intracellular Antibody Capture technol...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Bao, Leyuan, Hannon, Clare, Cruz-Mignoni, Abimael, Ptchelkine, Denis, Sun, Mei-yi, Miller, Ami, Bunjobpol, Wilawan, Quevedo, Camilo E., Derveni, Mariliza, Chambers, Jennifer, Simmons, Alison, Phillips, Simon E. V., Rabbitts, Terence H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715112/
https://ncbi.nlm.nih.gov/pubmed/29203900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16742-2
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