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Molecular mechanisms by which oxidative DNA damage promotes telomerase activity

Telomeres are highly susceptible to oxidative DNA damage, which if left unrepaired can lead to dysregulation of telomere length homeostasis. Here we employed single molecule FRET, single molecule pull-down and biochemical analysis to investigate how the most common oxidative DNA lesions, 8-oxoguanin...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Lee, Hui-Ting, Bose, Arindam, Lee, Chun-Ying, Opresko, Patricia L., Myong, Sua
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714237/
https://ncbi.nlm.nih.gov/pubmed/28981887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx789
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