Molecular mechanisms by which oxidative DNA damage promotes telomerase activity

Telomeres are highly susceptible to oxidative DNA damage, which if left unrepaired can lead to dysregulation of telomere length homeostasis. Here we employed single molecule FRET, single molecule pull-down and biochemical analysis to investigate how the most common oxidative DNA lesions, 8-oxoguanin...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nucleic Acids Res
Hlavní autoři: Lee, Hui-Ting, Bose, Arindam, Lee, Chun-Ying, Opresko, Patricia L., Myong, Sua
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714237/
https://ncbi.nlm.nih.gov/pubmed/28981887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx789
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky