Structural insight into the methyltransfer mechanism of the bifunctional Trm5

The wyosine derivatives present at position 37 in transfer RNAs (tRNAs) are critical for reading frame maintenance. The methyltransferase Trm5a from Pyrococcus abyssi (PaTrm5a) plays a key role in this hypermodification process in generating m(1)G37 and imG2, two products of the wyosine biosynthetic...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Wang, Caiyan, Jia, Qian, Zeng, Jianhua, Chen, Ran, Xie, Wei
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2017
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714064/
https://ncbi.nlm.nih.gov/pubmed/29214216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1700195
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