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Structural insights into the effects of 2′-5′ linkages on the RNA duplex

The mixture of 2′-5′ and 3′-5′ linkages generated during the nonenzymatic replication of RNA has long been regarded as a central problem for the origin of the RNA world. However, we recently observed that both a ribozyme and an RNA aptamer retain considerable functionality in the presence of prebiot...

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Библиографические подробности
Главные авторы: Sheng, Jia, Li, Li, Engelhart, Aaron E., Gan, Jianhua, Wang, Jiawei, Szostak, Jack W.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939906/
https://ncbi.nlm.nih.gov/pubmed/24516151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317799111
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