TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1

T cell expression of TIM-3 following Ag encounter has been associated with a continuum of functional states ranging from effector memory T cells to exhaustion. We have designed an in vitro culture system to specifically address the impact of anti–TIM-3/TIM-3 engagement on human Ag-specific CD8 T cel...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Sabins, Nina Chi, Chornoguz, Olesya, Leander, Karen, Kaplan, Fred, Carter, Richard, Kinder, Michelle, Bachman, Kurtis, Verona, Raluca, Shen, Shixue, Bhargava, Vipul, Santulli-Marotto, Sandra
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2017
Schlagworte:
Immune Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713500/
https://ncbi.nlm.nih.gov/pubmed/29127145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701030
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