Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling

The G protein-coupled receptor proteinase-activated receptor 2 (PAR2) has been implicated in various aspects of cellular physiology including inflammation, obesity and cancer. In cancer, it usually acts as a driver of cancer progression in various tumor types by promoting invasion and metastasis in...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Ungefroren, Hendrik, Witte, David, Rauch, Bernhard H., Settmacher, Utz, Lehnert, Hendrik, Gieseler, Frank, Kaufmann, Roland
Format: Artigo
Language:Inglês
Published: MDPI 2017
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713460/
https://ncbi.nlm.nih.gov/pubmed/29165389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18112494
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