Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer

TGF-β has a dual role in tumorigenesis, acting as a tumor suppressor in normal cells and in the early stages of tumor development while promoting carcinogenesis and metastasis in advanced tumor stages. The final outcome of the TGF-β response is determined by cell-autonomous mechanisms and genetic al...

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Bibliografiska uppgifter
I publikationen:J Clin Med
Huvudupphovsmän: Witte, David, Zeeh, Franziska, Gädeken, Thomas, Gieseler, Frank, Rauch, Bernhard H., Settmacher, Utz, Kaufmann, Roland, Lehnert, Hendrik, Ungefroren, Hendrik
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2016
Ämnen:
Review
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5184784/
https://ncbi.nlm.nih.gov/pubmed/27916875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm5120111
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