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Isomer activation controls stereospecificity of class I fructose-1,6-bisphosphate aldolases

Fructose-1,6-bisphosphate (FBP) aldolase, a glycolytic enzyme, catalyzes the reversible and stereospecific aldol addition of dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde 3-phosphate (d-G3P) by an unresolved mechanism. To afford insight into the molecular determinants of FBP aldolase stereo...

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Pubblicato in:J Biol Chem
Autori principali: Heron, Paul W., Sygusch, Jurgen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712624/
https://ncbi.nlm.nih.gov/pubmed/28972169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811034
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