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Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

In mitochondria, the sirtuin SIRT5 is an NAD(+)-dependent protein deacylase that controls several metabolic pathways. Although a wide range of SIRT5 targets have been identified, the overall function of SIRT5 in organismal metabolic homeostasis remains unclear. Given that SIRT5 expression is highest...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hershberger, Kathleen A., Abraham, Dennis M., Martin, Angelical S., Mao, Lan, Liu, Juan, Gu, Hongbo, Locasale, Jason W., Hirschey, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712617/
https://ncbi.nlm.nih.gov/pubmed/28972174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809897
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