Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model

Increasing NAD(+) levels by supplementing with the precursor nicotinamide mononucleotide (NMN) improves cardiac function in multiple mouse models of disease. While NMN influences several aspects of mitochondrial metabolism, the molecular mechanisms by which increased NAD(+) enhances cardiac function...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Martin, Angelical S., Abraham, Dennis M., Hershberger, Kathleen A., Bhatt, Dhaval P., Mao, Lan, Cui, Huaxia, Liu, Juan, Liu, Xiaojing, Muehlbauer, Michael J., Grimsrud, Paul A., Locasale, Jason W., Payne, R. Mark, Hirschey, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518566/
https://ncbi.nlm.nih.gov/pubmed/28724806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93885
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