Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich’s ataxia cardiomyopathy

INTRODUCTION: The childhood heart disease of Friedreich’s Ataxia (FRDA) is characterized by hypertrophy and failure. It is caused by loss of frataxin (FXN), a mitochondrial protein involved in energy homeostasis. FRDA model hearts have increased mitochondrial protein acetylation and impaired sirtuin...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Stram, Amanda R., Wagner, Gregory R., Fogler, Brian D., Pride, P. Melanie, Hirschey, Matthew D., Payne, R. Mark
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444842/
https://ncbi.nlm.nih.gov/pubmed/28542596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178354
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