SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

Among the features that distinguish type 1 innate lymphoid cells (ILC1s) from natural killer (NK) cells is a gene signature indicative of ‘imprinting’ by cytokines of the TGF-β family. We examined mice in which ILC1s and NK cells lacked SMAD4, a signal transducer that facilitates the canonical signa...

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Publicado no:Nat Immunol
Main Authors: Cortez, Victor S, Ulland, Tyler K, Cervantes-Barragan, Luisa, Bando, Jennifer K, Robinette, Michelle L, Wang, Qianli, White, Andrew J, Gilfillan, Susan, Cella, Marina, Colonna, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712491/
https://ncbi.nlm.nih.gov/pubmed/28759002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3809
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