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Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus
BACKGROUND: PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions. The PDE4 isoform PDE4B1 also interacts with the DISC1 prote...
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| Publicado no: | BMC Neurosci |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5712142/ https://ncbi.nlm.nih.gov/pubmed/29197324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-017-0396-6 |
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