Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantation

Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. In order to elucidate this relationship, whole exome sequencing (...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Koparde, Vishal, Abdul Razzaq, Badar, Suntum, Tara, Sabo, Roy, Scalora, Allison, Serrano, Myrna, Jameson-Lee, Max, Hall, Charles, Kobulnicky, David, Sheth, Nihar, Feltz, Juliana, Contaifer, Daniel, Wijesinghe, Dayanjan, Reed, Jason, Roberts, Catherine, Qayyum, Rehan, Buck, Gregory, Neale, Michael, Toor, Amir
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711034/
https://ncbi.nlm.nih.gov/pubmed/29194460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187771
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